DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.

DU-145 and PC-3 human prostate cancer cell lines express

Apr 17, 2006 · The majority of human prostate cancer cell lines, including the two «classical» cell lines DU-145 and PC-3, are reported to be androgen receptor (AR)-negative. However, other studies have provided evidence that the DU-145 and PC-3 cell lines express AR mRNA.

DU-145 and PC-3 human prostate cancer cell lines express

Expression of androgen receptor mRNA is detectable in DU-145 and PC-3 human prostate cancer cell lines. (A) A schematic representation of the human AR cDNA (the NCBI entry number M34233.1). The relative positions of the forward and the backward PCR primers in …

DU‐145 and PC‐3 human prostate cancer cell lines express

However, other studies have provided evidence that the DU‐145 and PC‐3 cell lines express AR mRNA. These contradictory observations prompted us to investigate whether DU‐145 and PC‐3 cell lines express the androgen receptor.

Published in: FEBS Letters · 2006Authors: Fatouma Alimirah · Jianming Chen · Zane Basrawala · Hong Xin · Divaker ChoubeyAffiliation: Edward Hines Jr Va HospitalAbout: Amino acid · Prostate cancer · Androgen receptor · Cell culture
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DU-145 and PC-3 human prostate cancer cell lines express

DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation Fatouma Alimiraha, Jianming Chena, Zane Basrawalab, Hong Xina, Divaker Choubeya,* a Department of Radiation Oncology, Loyola University Chicago & Edward Hines Jr. VA Hospital, 5th Avenue, Roosevelt Road,

DU-145 and PC-3 human prostate cancer cell lines express

The majority of human prostate cancer cell lines, including the two «classical» cell lines DU-145 and PC-3, are reported to be androgen receptor (AR)-negative.

Human Prostate Cancer Cell Lines | SpringerLink

Other modalities, including antibody-based therapy, gene therapy, and new chemotherapeutic drugs , have also been extensively tested at a preclinical level using human prostate cancer cell lines, either in vitro or grown as xenografts in various locations (orthotopic, in the femur) of nude or SCID mice. Such treatments are outside the scope of this chapter.

IFI16 in Human Prostate Cancer | Molecular Cancer Research

Alimirah F, Chen J, Basrawala Z, Xin H, Choubey D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Lett 2006; 580: 2294 –00.

Published in: Molecular Cancer Research · 2007Authors: Fatouma Alimirah · Jianming Chen · Francesca J Davis · Divaker ChoubeyAbout: Prostate cancer

Role of androgens and the androgen receptor in epithelial

Androgens are functionally required for the normal growth of the prostate gland and in prostate tumor development and progression. Epithelial-mesenchymal-transition (EMT) is an important process during normal development and in cancer cell metastasis induced by factors within the microenvironment, such as transforming growth factor-β (TGF-β).

DU145 – Wikipedia

DU145 (DU-145) is a human prostate cancer cell line. DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research. The DU145 cell line was derived from a central nervous system metastasis, of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy.

Hyperthermia-Induced Proteasome Inhibition and Loss of

Heat treatment of human prostate cancer cell lines led to rapid inhibition of 26S proteasome function in PC-3, DU-145, and LnCaP prostate cancer cells. This effect was independent of protein de novo synthesis as showing by a lack of an effect of cycloheximide and restricted to …

Expression of Androgen Receptor Is Negatively Regulated By p53

Alimirah F, Chen J, Basrawala Z, Xin H, Choubey D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation. FEBS Lett. 2006; 580:2294–2300.

Restoration of p53 Expression in Human Cancer Cell Lines

F Alimirah, J Chen, Z Basrawala, H Xin, D ChoubeyDU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Lett, 580 (2006), pp. 2294-2300.